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Marc Macaluso: Founder of TMW Longevity

Feb 253 min read

Updated: 1 day ago

Episode 55: From Tech to Longevity: How Marc of TMW Created a High-Quality, Absorbable Supplement for Optimal Health – Learn About His Formulation and What Truly Makes a High-Quality, Absorbable Supplement




Episode Highlights:


In this episode of the BiohackerBlondie Podcast, Jenny sits down with Marc, founder of TMW Longevity, to explore the science behind longevity supplements, bioavailability, and the essential ingredients that support healthspan. Marc shares his journey from tech entrepreneur to health advocate, why absorption is key in supplementation, and how TMW Longevity is setting a new standard for high-integrity, research-backed formulas.


Key Topics Discussed:


The Birth of TMW Longevity


  • How Marc transitioned from a successful tech career to launching a longevity-focused supplement company.

  • The inspiration behind TMW Longevity and why longevity is the "big canvas" of the future.

  • The role of demographic shifts, rising lifespans, and declining birth rates in shaping the longevity movement.


The Problem with Traditional Supplements


  • Lack of regulation and misleading claims in the supplement industry.

  • Why many supplements don’t contain the ingredients they claim.

  • How bioavailability plays a crucial role in whether a supplement is effective or wasted.


Breaking Down the TMW Longevity Formula


  • The science behind absorption and why liposomal technology ensures better nutrient uptake.

  • The importance of fat-soluble vitamins (like Vitamin D) and how TMW optimizes absorption.

  • Why hyaluronic acid supports both skin hydration and joint health—but only in its ultra-low molecular weight form.


Ingredient Deep Dive: Why These Were Chosen


  • Functional Mushrooms (Lion’s Mane, Chaga, Agaricus) – Brain function, immunity, and LDL reduction.

  • Taurine – Proven anti-aging properties that protect cells from degeneration.

  • Quercetin – A natural senolytic that helps remove damaged cells.

  • Magnesium Glycinate – Supports relaxation, sleep, and energy production.

  • Vitamin D – Essential for immune health, proven to boost levels when taken in the right form.

  • Vitamin C & B12 – Key nutrients for energy and cellular repair.

  • Agaricus Mushroom – Recognized for its potential anti-tumor properties.


The Science Behind Longevity & Optimization


  • Why longevity isn’t just about living longer but maintaining quality of life and compressing morbidity.

  • The importance of reducing inflammation (CRP levels) and optimizing thyroid health (TSH levels) for overall well-being.

  • How TMW Longevity improved key health markers in a 6-month blood test trial, showing:

    • 88% increase in Vitamin D levels

    • 15% reduction in LDL cholesterol

    • 21% decrease in inflammation (CRP levels)

    • 61% improvement in thyroid efficiency (TSH levels)

    • 13% boost in testosterone


Why Bioavailability Matters


  • How most powdered supplements fail to deliver nutrients efficiently.

  • The difference between powder-based formulas (like Novos, Blueprint, Athletic Greens) vs. liposomal technology.

  • Why fat-soluble ingredients need to be combined with the right delivery system.


TMW Longevity’s Commitment to High-Integrity Supplements


  • Why Marc removed resveratrol from the formula due to lack of human clinical data.

  • The dangers of supplement companies over-promising with trendy ingredients.

  • The importance of scientific rigor, transparency, and continuous formulation improvements.


Where to Find TMW Longevity


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